A child with an abdominal mass — Wilms tumour or neuroblastoma?

USG · CT · MRI

First and second year — the floor first, then every step

Find the organ of origin first (claw sign of the kidney, or displacement from outside it), then the discriminators — calcification, vessel encasement versus displacement, crossing the midline — and stage the spread.

Orient first

  • Age is the first clue: neuroblastoma is usually under 2 years, Wilms tumour typically 3–4 years; hepatoblastoma in infants.
  • Wilms tumour arises FROM the kidney (claw sign), displaces vessels, spreads into the renal vein and IVC, and calcifies rarely.
  • Neuroblastoma arises from the adrenal or sympathetic chain, ENCASES vessels, crosses the midline, calcifies in most cases, and may extend into the spinal canal through the foramina.

Acquire the study

  • Curvilinear and linear probes; colour Doppler of the renal vein and IVC.

The manoeuvre

  • Organ of origin: renal parenchyma stretched around the mass (claw sign) versus a separate mass indenting the kidney.
  • Echogenic foci with shadowing (calcification) favour neuroblastoma.
  • Colour Doppler: tumour thrombus in the renal vein and IVC up to the right atrium.
  • The other kidney (bilateral Wilms), the liver and nodes.

What confirms it

  • A mass whose origin and behaviour fit one entity, with the staging features listed.

What licenses you to exclude it

  • A normal ultrasound excludes a palpable solid mass; it does not stage one.

The classic misread

  • Missing a small contralateral renal lesion in a child with Wilms tumour.

See it on real cases

Direct links to Radiopaedia — the reference article and worked cases with their images. Each opens on Radiopaedia.

Key papers

Reviews and guidelines from RSNA, ESR and related journals. Each opens at its DOI.

  1. Guidelines for imaging and staging of neuroblastic tumors: consensus report from the International Neuroblastoma Risk Group Project ↗Brisse HJ, McCarville MB, Granata C, et al. · Radiology 2011RSNA · PubMed
  2. Imaging of Wilms tumor: an update ↗Servaes SE, Hoffer FA, Smith EA, et al. · Pediatric Radiology 2019SPR · ESPR · PubMed
  3. Imaging in neuroblastoma ↗Littooij AS, de Keizer B · Pediatric Radiology 2023SPR · ESPR · PubMed
  4. A review of neuroblastoma image-defined risk factors on magnetic resonance imaging ↗Chen AM, Trout AT, Towbin AJ · Pediatric Radiology 2018SPR · ESPR · PubMed

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