Planning an image-guided biopsy

CT · USG

First and second year — the floor first, then every step

Choose the modality that shows the target best, pick the shortest safe path that avoids vessels, bowel, pleura where possible and major nerves, and write down the pre-procedure checks — coagulation, the indication and the tissue the pathologist needs.

Orient first

  • Ultrasound is preferred when the target is visible — real-time needle tracking, no radiation, colour Doppler to avoid vessels; CT when the target is deep, behind gas or bone, or in the lung.
  • The safest path is not always the shortest: avoid crossing the pleura for an upper abdominal lesion, avoid bowel, and prefer a path through normal parenchyma for subcapsular liver lesions.
  • Coagulation thresholds and antithrombotic holding depend on the bleeding risk of the procedure — follow the current society guideline (for example SIR or CIRSE).

Acquire the study

  • Planning CT with a grid on the skin; low-dose intermittent CT or CT fluoroscopy during the procedure.

The manoeuvre

  • Planning axial slices: entry point, angle and depth in cm to the target.
  • Path check on axial and oblique reformats: pleura, bowel, vessels and nerves.
  • Coaxial needle placement with confirmation images of the tip within the target.
  • Post-procedure scan: pneumothorax (lung window), haematoma.

What confirms it

  • A documented path, needle position within the target, and the number and type of samples taken.

What licenses you to exclude it

  • A target that cannot be reached safely should be declared as such, with the alternative (another lesion, surgery, endoscopic sampling).

The classic misread

  • Sampling the necrotic centre of a mass — aim for the enhancing solid rim seen on the contrast study.

See it on real cases

Direct links to Radiopaedia — the reference article and worked cases with their images. Each opens on Radiopaedia.

Key papers

Reviews and guidelines from RSNA, ESR and related journals. Each opens at its DOI.

  1. Image-guided biopsy in the age of personalised medicine: strategies for success and safety ↗O'Shea A, Tam AL, Kilcoyne A, et al. · Clinical Radiology 2021RCR · PubMed
  2. Ultrasound-guided biopsy of challenging abdominopelvic targets ↗Lawrence EM, Lubner MG, Pickhardt PJ, et al. · Abdominal Radiology 2022SAR · PubMed
  3. Image-Guided Biopsy in Acute Diskitis-Osteomyelitis: A Systematic Review and Meta-Analysis ↗Chang CY, Pelzl C, Jesse MK, et al. · AJR 2023ARRS · PubMed
  4. Diagnostic Outcome of Image-Guided Percutaneous Core Needle Biopsy of Sclerotic Bone Lesions: A Meta-Analysis ↗Suh CH, Yun SJ · AJR 2019ARRS · PubMed

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